Purified Anti-Mouse CD279 Antibody[RMP1-14], Functional Grade (AN007850)
![Purified Anti-Mouse CD279 Antibody[RMP1-14], Functional Grade - 1](http://file.elabscience.com/assets/images/loading.png)
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD279 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells), Block Reported in the literature |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM, Block |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CD279 protein |
| Abbre | CD279 |
| Synonyms | CD279 antigen, hPD 1, hPD l, Ly101, PD 1, Pdc1, PDCD 1, Programmed cell death 1 protein, Protein PD 1, Protein PD-1, Systemic lupus erythematosus susceptibility 2, hPD, mPD, Programmed Death, Programmed cell death, Programmed cell death protein, PDCD, hSLE, SLEB, PD-1, CD279, hPD-1, hPD-l, hSLE1, mPD-1, Programmed cell death 1, Programmed cell death protein 1, Programmed Death-1, SLEB2, Pd1, Pdcd1 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Clone | RMP1-14 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| E-AB-F11310 | Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12], Functional Grade | 29F.1A12 |
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